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課程名稱 |
結構生物學概論
Introduction to Structural Biology |
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開課學期 |
111-1 |
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授課對象 |
生化科技研究所 |
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授課教師 |
楊啟伸 |
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課號 |
BST5008 |
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課程識別碼 |
B22EU0180 |
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班次 |
01 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期四6,7(13:20~15:10) |
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上課地點 |
農化二B10-1 |
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備註 |
本課程以英語授課。碩士班A群組必修10學分課程之一。
總人數上限：80人 |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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課程概述 |
This is a class integrates the concepts of structural biology and bioinformatics. There are four major parts: 1) The basic principles of how 20 amino acids affect protein structures. 2) The modern methods currently adopted to resolve atomic resolution of protein structures will be explained. 3) Software tools for protein structure display and analysis, mainly using UCSF ChimeraX, will be demonstrated. Several bioinformatics concepts and web servers will be mentioned in this class. 4) The mechanism behind protein structure and functional exertion will be emphasized and exercised via student presentations. |
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課程目標 |
1. Understand amino acids and protein structures
2. Modern approaches to resolve protein structure
3. Protein structure and function
4. Resolve a protein structure by yourself (in the class)
5. Software-based analysis of protein sequence
6. Create a video showing protein in action
7. Current developments of protein structural-related bioinformatics methods.
8. Do a structure-based presentation |
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課程要求 |
This class will be taught in English. |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註： This class mainly does Q&A thorugh e-mail. |
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指定閱讀 |
Newly published journal articles. |
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參考書目 |
1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Arthur M. Eesk (2016). Introduction to Protein Sciuence, 3rd ed., Oxford University Press, Oxford, United Kindom.
3. Materials are updated according to selected most updated journal publications. |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Final Exam |
30% |
Written Exam, Take-home/Open-book style |
2. |
Personal Report |
20% |
Protein structural analysis with software tools taught in this class |
3. |
Presentation |
20% |
Presentation of an assigned topic in Engilsh |
4. |
Mid-term |
30% |
Written Exam |
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